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Sunday, April 2, 2017

Recent advances in Parkinson's disease therapy


Abstract (as presented by the author of the scientific work):

"This article summarizes (1) the recent achievements to further improve symptomatic therapy of motor Parkinson's disease (PD) symptoms, (2) the still-few attempts to systematically search for symptomatic therapy of non-motor symptoms in PD, and (3) the advances in the development and clinical testing of compounds which promise to offer disease modification in already-manifest PD. However, prevention (that is, slowing or stopping PD in a prodromal stage) is still a dream and one reason for this is that we have no consensus on primary endpoints for clinical trials which reflect the progression in prodromal stages of PD, such as in rapid eye movement sleep behavior disorder (RBD) -a methodological challenge to be met in the future."


Covered topics (the letter size corresponds to the frequency of mentioning in the text):





Conclusions (as presented by the author of the scientific work):

"Neurologists have to accept that the majority of patients with PD, even at the very early stage of neurological diagnosis, actually present a late-stage phenotype of an alpha-synucleinopathy. Thus, PD has started at least 20 years before it manifests in the clinic with its motor symptoms. Neurologists will likely have to shift their clinical and diagnostic focus away from the dopaminergic system to symptoms related to different parts of the nervous system, such as the enteric system62, the brainstem with its autonomic control areas, the locus coeruleus57, or even the skin. If the dream of a disease-modifying therapy is to come true, neuroscience, drug development, and physician scientists face at least two challenges. First, drug development will target the aggregation and propagation of alpha-synuclein and of related mechanisms as well as mitochondrial dysfunction; second, a major effort has to be made to enhance the diagnostic methodology in order to identify a primary endpoint for clinical neuroprotective trials, not only in early motor PD but also in the prodromal stages of PD82–84. It has never been so exciting as today to work in the field of PD, and we should share this belief with the patients we diagnose, treat, and care for."


Full-text access of the referenced scientific work:

Oertel WH. Recent advances in treating Parkinson's disease. F1000Res. 2017 Mar
13;6:260. doi: 10.12688/f1000research.10100.1. eCollection 2017. Review. PubMed
PMID: 28357055; PubMed Central PMCID: PMC5357034.
https://f1000research.com/articles/6-260/v1


Webmaster:

Prof. Atanas G. Atanasov (Dr. habil., PhD)
https://about.me/Atanas_At


17 comments:

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    1. I have been suffering from (HEPATITIS B) disease for the last four years and had constant pain, especially in my knees. During the first year, I had faith in God that I would be healed someday.This disease started to circulate all over my body and I have been taking treatment from my doctor, a few weeks ago I came on search on the internet if I could get any information concerning the prevention of this disease, on my search I saw a testimony of someone who has been healed from (HERPES and Cancer) by this Man DR OSE and she also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so I wrote to DR OSE telling him about my (HEPATITIS B) he told me not to worry that I was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man few weeks later I started experiencing changes all over me as the DR assured me that I have cured, after some time i went to my doctor to confirmed if I have been finally healed behold it was TRUE, So friends my advice is if you have such sickness or any other at all you can email DR OSE on( droseherbalcurehome@gmail.com sir I am indeed grateful for the help I will forever recommend you to my friends!!! with your lovely Email Address (droseherbalcurehome@gmail.com or you can also WhatsApp him on this number +2348164222865 ,.,

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  2. I am 56 year old who was diagnosed 4 years ago with Parkinson's. I had severe calf pain, muscle pain, slurred speech, frequent falls, loss of balance, difficulty in getting up from sitting position, i was having a problem accepting my diagnosis, even though I read every thing I could find to read. I was put on Sinemet 3 times daily but it doesn't seem to be helping. I also had difficulty writing now. Getting in bed, turning over. i have had good luck with the other meds like Mirapex, but I was extremely tired of it. I have also noticed cognitive decline, but that is also related to a now-removed brain tumor.As the disease progressed all medication stopped working, i was introduced to Health herbal clinic in Johannesburg who have successful herbal treatment to Parkinson's and other lungs diseases. I spoke to few people who used the treatment here in USA and they all gave a positive response, so i immediately purchased the P.D herbal remedy and commenced usage, i used the herbal supplement for only 8 weeks, all symptoms were unbelievably reversed, herbs are truly gift from God. contact this herbal clinic via their email healthherbalclinic @ gmail. com or visit www. healthherbalclinic. weebly. com

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  3. I am very happy to share this triumphant testimony on how i was cured on Parkinson, i never believed i was ever going to be cured from Parkinson. after being diagnosed, and i was penalized on how i will ever regain my self back back after suffering for 3 years of Parkinson . finally Dr Abumere cure gave me a reason to be happy again after searching online then i found out that Dr Abumere has save many lives of this disease. behold i was filled with Joy after writing to him on his email and visited his website and he responded to me that i shouldn’t be skeptical that my disease is very simple for him to handle. i hold on to his words then i attended to every of his instruction then i purchase the herbal medicine from him in south africa that is how my medicine was send to me via delivery service and he assured me after using his HERBAL MEDICINE in just 29 days i will be cured and i will come back and thank him, i went to check myself after 29 days although before the date i was really experiencing body release and my doc confirmed me Parkinson Negative.
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  4. I was diagnosed with Parkinson's disease in my mid to late 40's. I had hand tremors for several years. Gradually became worse. I then noticed when I was tired the tremors were worse. I started falling for no apparent reason. I now have stiffness in my legs and need to walk with 2 canes or a walker. I am very slow getting around. I am now 52 years old. I am forgetful at times and have difficulty expressing myself. I have difficulty swallowing at times. I become tired easily, I also become quite dizzy when performing any athletic function (jogging). I was on Levodopa/Carbidopa, 100/25. nothing was really working to help my condition. Finally i started on parkinson's natural herbal formula i ordered from Health HERBAL CLINIC, i read alot of great reviews from other patients who used the parkinson's herbal treatment. My symptoms totally declined over a 4-5 weeks use of the Health herbal clinic Parkinsons disease natural herbal formula. , its effects on parkinson's is amazing, all My symptoms gradually faded away, I have been active and hope to continue! (Visit www. healthherbalclinic. net or email at Info@ healthherbalclinic. net) I recommend this Parkinson's herbal formula for all Parkinson's Patients.

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  5. ALL THANKS TO DR WILLIAMS WITH HIS HERBAL PORTION I WAS CURED FROM COPD.
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  6. I was diagnosed with Parkinson's disease a year ago at the age of 68. For several months I had noticed tremors in my right hand and the shaking of my right foot when I was sitting. My normally beautiful cursive writing was now small cramped printing. And I tended to lose my balance. Neurologist had me walk down the hall and said I didn't swing my right arm. I had never noticed! I was in denial for a while as there is no history in my family of parents and five older siblings, but now accept I had classic symptoms. I was taking pramipexole (Sifrol), carbidopa/levodopa and Biperiden, 2 mg. and started physical therapy to strengthen muscles. nothing was really working to help my condition.I went off the Siferol (with the doctor’s knowledge) and started on parkinson’s herbal formula i ordered from Health Herbal Clinic, my symptoms totally declined over a 5 weeks use of the Parkinsons disease natural herbal formula. i am now almost 70 and doing very well, the disease is totally reversed!! Visit there website www . healthherbalclinic . net

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  9. I was recently free from Chronic obstructive pulmonary disease(emphysema)if not from total cure herbal foundation,i suffered with copd emphysema disease for over 9yrs which i smoke for 29 years,it wasn't easy in anyway living with this deadly disease,i cried for help everyday which i also spend almost all my money on, i was at the point i nearly gave up because i heard a lot of stories that there was no cure for it,i tried all the medications doctor around gave to me yet nothing happened tho it was able to be control at least,august 23th 2017 i came across an article someone explaining how she was cured by TOTAL CURE HERBAL FOUNDATION in Joburg,so i contacted totalcureherbalfoundation @ gmail. com....and their website ....https :/ /totalcureherbalfou .wixsite.com /website to see if this was true,but right now i;m here giving the same similar testimony on how they gave me alternative way to cure this disease with their organic natural herbal products without any side effect,do email them now to see for yourself.

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  10. I am 63 years old, I was diagnosed of Parkinsons disease at the age of 57. I had severe calf pain, muscle pain, slurred speech, frequent falls, loss of balance, difficulty getting up from sitting position. I was placed on Sinemet 3 times daily, it helped me but not very much. My neurologist advised me to try natural treatments and introduced me to NewLife Clinic Parkinsons Disease Herbal formula, I read alot of positive reviews from other patients who used the treatment and i immediately started on the treatment. I had great improvement and relief with this treatment, total decline of symptoms. Great improvement with speech, co-ordination, balance, muscle, mood etc, I gained back my life with this treatment and can never be thankful enough. Visit NewLife Clinic official website ww w. newlifeherbalclinic. com.

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  11. I want to give a testimony on how I got cured from Parkinson's disease. Few months back I was having some symptoms . I went to see a doctor and many blood tests was done on me, later on I was told I had Parkinson's disease. My doctor told me that there's no cure for Parkinson's disease I felt bad, I went online searching for a possible cure for Parkinson's disease, I saw a post of Dr Bello, a herbal doctor that's helping people get cured from Parkinson, HPV, HIV, HEPATITIS B, CANCER e.t.c. i contacted him and told him how I'm feeling he said his herbal medicine can cure me. He sent me the medicine via Dhl delivery service and I received the medicine some days after he sent it, i took the medicine as prescribed by him. Before the completion of the medication the symptoms stopped. I went to the doctor and carried out another blood test, surprisingly I was Negative. I haven't had any symptoms anymore. Dr. Bello is great and you can contact via (bellospelltemple@gmail.com) whatsApp him via +2348147271779;

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  12. I want to give a testimony on how I got cured from Parkinson's disease. Few months back I was having some symptoms . I went to see a doctor and many blood tests was done on me, later on I was told I had Parkinson's disease. My doctor told me that there's no cure for Parkinson's disease I felt bad, I went online searching for a possible cure for Parkinson's disease, I saw a post of Dr Bello, a herbal doctor that's helping people get cured from Parkinson, HPV, HIV, HEPATITIS B, CANCER e.t.c. i contacted him and told him how I'm feeling he said his herbal medicine can cure me. He sent me the medicine via Dhl delivery service and I received the medicine some days after he sent it, i took the medicine as prescribed by him. Before the completion of the medication the symptoms stopped. I went to the doctor and carried out another blood test, surprisingly I was Negative. I haven't had any symptoms anymore. Dr. Bello is great and you can contact via (bellospelltemple@gmail.com) whatsApp him via +2348147271779;

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  13. Good day to all viewer online am cindy jesae From USA..Texas am so happy sharing this great testimony on how i was checking for solution in the internet then miraculously i came Across Dr.Bello the powerful herbalist that Cure parkinson individuals Herpes Simplex Virus,so I contacted him base on the testimonies I?m seeing about him on the internet,Good to say i was cured too by his herbal medicine, kindly contact him today through his email he can help you..bellospelltempl@gmail.com and he can also cure any types of diseases like,HEPATITIS B,DIABETICS,CANCER,HPV,LOW SPERM CAM.. all thank to you Dr Bello for your kindly help in my life, you can also contact him on whatsApp with his number +2348147271779 good luck.

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  14. Good day to all viewer online am cindy jesae From USA..Texas am so happy sharing this great testimony on how i was checking for solution in the internet then miraculously i came Across Dr.Bello the powerful herbalist that Cure parkinson individuals Herpes Simplex Virus,so I contacted him base on the testimonies I?m seeing about him on the internet,Good to say i was cured too by his herbal medicine, kindly contact him today through his email he can help you..bellospelltempl@gmail.com and he can also cure any types of diseases like,HEPATITIS B,DIABETICS,CANCER,HPV,LOW SPERM CAM.. all thank to you Dr Bello for your kindly help in my life, you can also contact him on whatsApp with his number +2348147271779 good luck.

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  15. My husband was diagnosed with Parkinson's disease nearly 7 years ago, when he was 49. He had a stooped posture, tremors, right arm does not move and also has a pulsating feeling in his body. He was placed on Sinemet for 8 months and then Sifrol was introduced which replaced the Sinemet. During this time span he was also diagnosed with dementia. He started having hallucinations, and lost touch with reality.I searched for alternative treatments and and started him on Parkinson's herbal formula i ordered from Health Herbal Clinic, Just 7 weeks into the Herbal formula treatment he had great improvements with his slurred speech, there is no case of Rigid muscles and Slowed movement (bradykinesia) since treatment, visit Health Herbal Clinic official website www. healthherbalclinic. net or email info@ healthherbalclinic. net. This treatment is incredible!

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  16. i want to inform the public how i was cured from (HERPES SIMPLEX VIRUS) by Dr Ekpiku, i visited different hospital but they gave me list of drugs like Famvir, Zovirax, and Valtrex which is very expensive to treat the symptoms and never cured me. I was browsing through the Internet searching for remedy on herpes and i saw comment of people talking about how Dr Ekpiku cured them. when i contacted him he gave me hope and send a Herbal medicine to me that i took and it seriously worked for me, am a free person now without problem, my herpes result came out negative. I pray for you Dr Ekpiku, am cured you can also get your self cured my friends if you really need Dr Ekpiku help, you can reach him now on ekpikuspellhomeofgrace@gmail.com or call or Text 650) 653-8578.

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